Direkt von der offiziellen Guitar Hero 5 Website kommt die Band und Künstlerliste welche in Guitar Hero 5 zu finden sein wird. Einige der Künstler: The Rolling Stones, The White Stripes, Kings of Leon, Tom Petty, Bob Dylan, Johnny Cash, Santana und Vampire Weekend.
- 3 Doors Down
- A Perfect Circle
- AFI
- Arctic Monkeys
- Attack! Attack! UK
- Band Horses
- Beastie Boys
- Beck
- Billy Idol
- Billy Squier
- Blink-182
- Blur
- Bob Dylan - All Along The Watchtower
- Bon Jovi
- Brand New
- Bush
- Children Of Bodom
- Coldplay
- Darker My Love
- Darkest Hour
- David Bowie
- Deep Purple
- Dire Straits
- Duran Duran
- Eagles Of Death Metal
- Elliott Smith
- Elton John
- Face To Face
- Garbage
- Gorillaz
- Gov’t Mule
- Grand Funk Railroad
- Iggy Pop
- Iron Maiden
- Jeff Beck
- Jimmy Eat World
- John Mellencamp
- Johnny Cash
- Kaiser Chiefs
- King Crimson
- Kings Of Leon - Sex on Fire
- Kiss
- Love and Rockets
- Megadeth
- Mötley Crüe
- Muse
- My Morning Jacket
- Nirvana
- No Doubt
- Peter Frampton
- Public Enemy Featuring Zakk Wylde
- Queen & David Bowie
- Queens Of The Stone Age
- Rammstein
- Rose Hill Drive
- Rush
- Santana - No One To Depend On (LIVE)
- Scars On Broadway
- Screaming Trees
- Smashing Pumpkins
- Sonic Youth
- Spacehog
- Stevie Wonder
- Sublime
- Sunny Day Real Estate
- T. Rex
- The Bronx
- The Derek Trucks Band
- The Duke Spirit
- The Killers
- The Police
- The Raconteurs
- The Rolling Stones - Sympathy for the Devil
- The Sword
- The White Stripes - Blue Orchid
- Thin Lizzy
- Thrice
- Tom Petty - Runnin Down a Dream
- Tom Petty & The Heartbreakers
- TV On The Radio
- Vampire Weekend - A-Punk
- Weezer
- Wild Cherry
- Wolfmother